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Lung cancer is the leading cause of cancer death in the United States.1 While surgery has historically been an alternative considered the gold standard of treatment, its application is frequently limited by the patient’s health and the stage and location of the tumor. Supported by compelling scientific evidence, Hypofractionated high-dose radiolsurgery, which is emerging as a groundbreaking treatment alternative – showing evidence of improved tumor control and patient survival when compared to conventional radiotherapy.2 Safely delivering lung radiosurgery presents considerable challenges given continuous respiratory-induced motion and significant surrounding healthy tissue. As a proven solution for treating medically inoperable lung cancer patients and those seeking an alternative to surgery, the CyberKnife® Robotic Radiosurgery System stands alone in addressing these challenges – setting new standards for accuracy, conformality, and respiratory motion tracking. 3

Improved Tumor Control and Survival

Scientific evidence has demonstrated a direct relationship between survival and efficacy with radiosurgical dose escalations of greater than 100 Gy BED. However, dose escalation for treating lung tumors has historically been limited by the destruction of normal tissue resulting from the large treatment margins commonplace with conventional, gantry based radiation therapy systems.

Unparalleled Healthy Tissue Preservation

Unlike the respiratory gating and breath-holding techniques of gantry systems, the CyberKnife® delivers tightly contoured beams that move precisely with tumor motion throughout the respiratory cycle. Integrating the Synchrony® Respiratory Tracking System, margins are limited to only that which are clinically relevant, dramatically decreasing the targeting and set-up margins typical with other respiratory compensation techniques. And with the 4D treatment planning capabilities of the CyberKnife, tumor and surrounding structure motion and deformation are accounted for throughout the entire breathing cycle. Ultimately, the combination of these capabilities helps to ensure prescribed doses are limited to the intended target while maximizing healthy tissue preservation.

Where conventional gantrybased imaging systems such as IGRT and cone-beam CT provide image guidance for pre-treatment set-up, target movements during the treatment remain unrecognized with these technologies. Using advanced robotic technology, the CyberKnife is the only system to utilize continual image guidance to automatically track, detect, and correct for target movements throughout the treatment. This intra-fraction image guidance capability unique to the CyberKnife has proven to deliver an unprecedented 0.7 mm targeting accuracy when treating targets that move with respiration.

Completely Non-Invasive Capabilities

Significantly reducing the need for external frames or implanted fiducials the CyberKnife is the only system to directly track lung tumors with radiosurgical accuracy. Using sophisticated image processing and registration, most tumors can be tracked non-invasively – eliminating the risks associated with fiducial implantation while expediting the patient’s time to treatment.