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In the United States, brain metastases affect nearly 170,000 individuals per year.1 Primary benign brain
umors and malignancies constitute an additional 39,000 cases annually.2 While surgery, chemotherapy, and radiation therapy have historically been the standard of care, radiosurgery has emerged as a revolutionary treatment for intracranial lesions. The CyberKnife® Robotic Radiosurgery System has proven to be a leader in setting new standards for radiosurgical accuracy, conformality, and versatility.

Unprecedented Targeting Accuracy

Many modern radiosurgery systems now incorporate “frameless” capabilities, however, most fail to adequately manage submillimetric intra-fraction movements common with non-invasive intracranial immobilization. Where technologies such as IGRT and cone beam CT provide pre-treatment set-up image guidance, target movements during the treatment remain unrecognized, which may result in an increased risk of toxicity to sensitive structures. The CyberKnife has revolutionized frameless intracranial radiosurgery as the only system capable of continual image guidance to automatically track, detect, and correct for intrafraction target movements throughout the treatment. With this unique image guidance technology, the CyberKnife has proven to maintain an unprecedented 0.31 mm targeting accuracy treating intracranial lesions in independent, peer reviewed studies. Most remarkable,
this accuracy applies to both spherical and non-spherical targets, where radiosurgical targeting accuracy has proven to erode using multiple isocenters via conventional radiosurgery systems.

Unrivaled Dose Conformality

For more than 30 years, radiosurgery technical research and clinical studies have demonstrated that a large array of uniquely angled beams enhances dose conformality while reducing the risks of dose toxicity. Unconstrained by the clockwise/ counterclockwise gantry rotations of conventional radiation therapy equipment, the robotic mobility of the CyberKnife extends these proven benefits by delivering diverse non-coplanar treatments routinely in daily clinical practice. Unlike the 7 to 9 beam plans commonplace with gantry based systems, a typical CyberKnife treatment includes more than 100 uniquely angled, highly focused beams per fraction.

Where isocentric treatment delivery is common for treating large radiotherapy fields and spherical targets, this technique is often not optimal for treating targets of complex shapes – especially with radiosurgical doses and when radiosensitive structures are in close proximity. As the only system capable of delivering both isocentric and non isocentric treatments, the CyberKnife has an unparalleled ability to precisely sculpt delivered dose around sensitive critical structures.

Expanded Neurosurgical Applications

Similar to cobalt-based systems, the CyberKnife treats a wide variety of intracranial indications including benign, primary malignant, and metastatic tumors, as well as vascular and functional disorders. However, the versatility of CyberKnife extends its capabilities to a significantly broader patient population:
▲ The need to deliver more than a single fraction is often imperative, particularly when intracranial targets are surrounded by other radio-sensitive structures. The CyberKnife offers the flexibility to efficiently and painlessly deliver both single and multiple fraction treatments.
▲ The completely non-invasive nature of the CyberKnife enables the treatment of intracranial targets for pediatric patients – providing a safe, painless and non-claustrophobic experience.
▲ Unconstrained by a fixed hemisphere, the CyberKnife delivers complete intracranial access – keeping extreme peripheral targets always within reach.
▲ With unhindered robotic mobility, the CyberKnife extends its reach beyond the head to all levels of the spine – cervical through sacral.